Obstructive Sleep Apnea Syndrome (OSAS) is an increasingly prevalent global disorder characterized by recurrent interruptions in breathing during sleep. Continuous Positive Airway Pressure (CPAP) is widely regarded as the most effective treatment, particularly for severe cases. Despite its efficacy, adherence to CPAP therapy remains alarmingly low, with less than 50% of patients successfully adapting to the device. Studies attribute this issue to two primary factors: physical discomfort caused by the CPAP mask and the lack of emotional connection between the mask design and patients’ psychological and emotional needs. This study addresses these challenges by employing Kansei Engineering, a user-centered methodology that integrates emotional design principles into product development, to enhance the design of CPAP masks. The objective is to create masks that not only fulfill functional requirements but also evoke positive emotional responses, thereby improving user experience and treatment adherence. The research process involved the application of Semantic Differential (SD) methods to assess users’ emotional perceptions of six CPAP mask designs. From an initial pool of 130 descriptive words, 30 emotionally significant adjectives were distilled through expert consultation. These words were paired into 12 bipolar semantic scales and incorporated into a questionnaire to evaluate the masks. A sample of 30 users completed the survey, providing ratings on a seven-point Likert scale. Subsequent statistical analysis utilized multivariate methods, including Correlation Coefficient Analysis (CCA), Principal Component Analysis (PCA), and Factor Analysis (FA), to identify the key emotional attributes influencing mask design. Findings revealed that the most critical attributes included safety, compatibility, modernity, and aesthetic harmony. These attributes guided the refinement of mask designs to meet both functional and emotional user expectations. The results demonstrate that integrating emotional design through Kansei Engineering significantly enhances the user experience by aligning product characteristics with the emotional and physical needs of users. By translating abstract emotional responses into concrete design elements, Kansei Engineering bridges the gap between functionality and user satisfaction. The implications of this study extend beyond the medical field. Kansei Engineering offers a robust framework for integrating user emotions into the design process, making it applicable across various industries. By addressing emotional and psychological factors, designers can create products that resonate with users on a deeper level, fostering greater acceptance and long-term engagement. This approach underscores the importance of considering emotional design as a core component of product development, particularly for medical devices where user compliance is critical to treatment success. In conclusion, this study highlights the potential of Kansei Engineering to revolutionize CPAP mask design by prioritizing user emotions alongside functional performance. The findings emphasize that emotionally responsive designs not only enhance user satisfaction but also contribute to higher adherence rates, thereby improving health outcomes for patients with obstructive sleep apnea. This research serves as a valuable reference for future studies seeking to integrate emotional design principles into medical product development and beyond.